Single Biggest Cancer Dictionary in the World

What is

CpG oligodeoxynucleotide TLR9 agonist DV281

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Pronunciation: /cpg* oligodeoxynucleotide* tlr* naɪn ˈægənɪst dv* tu ˈhənərd ənd eighty-one*/

CpG oligodeoxynucleotide TLR9 agonist DV281

Definition

A proprietary synthetic, aerosolized C-class CpG oligodeoxynucleotide-based (ODN) agonist of toll-like receptor 9 (TLR9), with potential immunostimulating activity. Upon inhalation, CpG ODN TLR9 agonist DV281 specifically targets, binds to and activates TLR9 expressed by plasmacytoid dendritic cells (pDCs) and B-cells. This initiates immune signaling pathways and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against antigens expressed by lung cancer cells. TLR9, a member of the TLR family, plays a fundamental role in pathogen recognition and activation of the innate immune system.