Definition

A radioconjugate composed of macrophage-targeted polyglucose nanoparticle, labeled with the radioisotope copper Cu 64, with potential use as a tracer for macrophages including tumor-associated macrophages (TAMs) during positron emission tomography (PET). Upon administration of copper Cu 64-labeled macrophage-targeted nanoparticle, the macrophage-targeted nanoparticle is taken up by macrophages, including TAMs in the tumor microenvironment (TME). Upon PET imaging, the macrophages can be detected. The accumulation of macrophages is present in various inflammatory diseases and tumors.