Single Biggest Cancer Dictionary in the World
What is
cisplatin micelle formulation HA132
?Pronunciation: /cisplatin* micelle* ˌfɔrmjəˈleɪʃən hɑ wən ˈhənərd ənd thirty-two*/
cisplatin micelle formulation HA132
Definition
A micelle formulation containing the inorganic platinum agent cisplatin, with potential antineoplastic activity. Upon administration, cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and growth inhibition of tumor cells.