Single Biggest Cancer Dictionary in the World
What is CHK1 inhibitor PF-477736?
Pronunciation: /chk* wən ˌɪnˈhɪbətər pf* fɔr ˈhənərd ənd seventy-seven* ˈθaʊzənd, ˈsɛvən ˈhənərd ənd thirty-six*/
CHK1 inhibitor PF-477736
Definition
A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity. Chk1 inhibitor PF-477736 inhibits chk1, an ATP-dependent serine-threonine kinase that is a key component in the DNA replication-monitoring S/G2 checkpoint system. By overriding the last checkpoint defense against DNA damaging agent-induced lethal damage, chk1 inhibitor PF-477736 may potentiate the antitumor efficacy of various chemotherapeutic agents against tumor cells with intrinsic checkpoint defects.