Single Biggest Cancer Dictionary in the World
What is
CD30 CAR-expressing autologous T lymphocytes
?Pronunciation: /ˈsiˈdi ˈθərˌdi kɑr ɪkˈsprɛsɪŋ autologous* ti ˈlɪmfəˌsaɪts/
CD30 CAR-expressing autologous T lymphocytes
Definition
A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the CD30 antigen, with potential immunostimulating and antineoplastic activities. Upon administration, the CD30 CAR-expressing autologous T lymphocytes specifically recognize and bind to CD30-expressing tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies.