Single Biggest Cancer Dictionary in the World
What is CBL-B inhibitor-treated autologous tumor-infiltrating lymphocytes DeTIL-0255?
Pronunciation: /cbl* bi ˌɪnˈhɪbətər ˈtritɪd autologous* ˈtumər ˌɪnˈfɪlˌtreɪtɪŋ ˈlɪmfəˌsaɪts detil* tu ˈhənərd ənd fifty-five*/
CBL-B inhibitor-treated autologous tumor-infiltrating lymphocytes DeTIL-0255
Definition
A preparation of autologous tumor-infiltrating lymphocytes (TILs) derived from a patient’s tumor that have been treated ex vivo during cell expansion with NX-0255, an inhibitor of Casitas B-lineage lymphoma proto-oncogene-b (CBL-B), with potential immunomodulating and antineoplastic activities. Upon administration, the CBL-B inhibitor-treated autologous TILs DeTIL-0255 specifically recognize and kill the patient’s tumor cells. NX-0255 enhances TIL expansion and the tumor-killing ability of the TILs when returned to the patient.