Definition

A radiotracer consisting of nicotine radiolabeled with the positron-emitting isotope carbon C11, with potential imaging use upon positron emission tomography/computed tomography (PET/CT). Upon administration via inhalation, carbon C11 nicotine binds to nicotine receptors in the lungs. Upon PET/CT the binding, pulmonary distribution, and clearance of nicotine in the lungs can be assessed.