Definition

An orally bioavailable and selective inhibitor of the receptor tyrosine kinase AXL (UFO), with potential antineoplastic activity. Upon oral administration, AXL inhibitor NTQ2494 targets, binds to and prevents the activation of AXL. This blocks AXL-mediated signal transduction pathways, and inhibits AXL-mediated tumor cell growth, proliferation and migration, and AXL-mediated immunosuppression and immune evasion. AXL, a member of the Tyro3, AXL and Mer (TAM) family of receptor tyrosine kinases, is overexpressed by many tumor cell types and a variety of immune cells. It plays a key role in tumor cell proliferation, survival, invasion and metastasis, and its expression is associated with drug resistance and poor prognosis.