Single Biggest Cancer Dictionary in the World

What is

autologous TCR-engineered T cells IMA202

?

Pronunciation: /autologous* tcr* ˌɛnʤəˈnird ti sɛlz ima* tu ˈhənərd ənd tu/

autologous TCR-engineered T cells IMA202

Definition

A preparation of autologous T lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) targeting patient-specific tumor associated antigens (TAAs), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous TCR-engineered T cells IMA202 specifically recognize and bind to the TAA on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the TAA-positive cancer cells.