Definition

A preparation of autologous cytotoxic T lymphocytes (CTLs) genetically modified to target a not yet disclosed ovarian cancer-specific tumor-associated antigen (TAA), with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the autologous ovarian cancer-specific cytotoxic T lymphocytes (OC-CTLs) bind to and induce selective toxicity in tumor cells expressing the TAA.