Single Biggest Cancer Dictionary in the World
What is
autologous HBV-specific TCR-expressing T lymphocytes SCG101
?Pronunciation: /autologous* hbv* spɪˈsɪfɪk tcr* ɪkˈsprɛsɪŋ ti ˈlɪmfəˌsaɪts scg* wən ˈhənərd ənd wən/
autologous HBV-specific TCR-expressing T lymphocytes SCG101
Definition
A preparation of human autologous T lymphocytes transduced with a retroviral vector encoding for a T-cell receptor (TCR) specific for HLA-A*02-restricted human hepatitis B virus (HBV) surface antigen (HBsAg) peptide, with potential antineoplastic activity. Upon administration, the autologous HBV-specific TCR-expressing T lymphocytes SCG101 recognize and bind to HBV antigen-positive cells, which induces cytotoxic T-lymphocyte (CTL)-mediated elimination of HBV antigen-positive cells, including those in HBV-related hepatocellular carcinoma (HCC).