Single Biggest Cancer Dictionary in the World
What is
autologous anti-FLT3 CAR T cells TAA05
?Pronunciation: /autologous* ˈænˌti flt* θri kɑr ti sɛlz taa* faɪv/
autologous anti-FLT3 CAR T cells TAA05
Definition
A preparation of autologous T lymphocytes genetically engineered with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-FLT3 CAR T cells TAA05 target and bind to tumor cells expressing FLT3, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of FLT3-expressing tumor cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias (AMLs).