Single Biggest Cancer Dictionary in the World
What is aurora kinase inhibitor PF-03814735?
Pronunciation: /ərˈɔrə kinase* ˌɪnˈhɪbətər pf* θri ˈmɪljən, eɪt ˈhənərd ənd ˌfɔrˈtin ˈθaʊzənd, ˈsɛvən ˈhənərd ənd ˈθərdiˌfaɪv/
aurora kinase inhibitor PF-03814735
Definition
An aurora kinase inhibitor with potential antineoplastic activity. PF-03814735 binds to and inhibits aurora kinases, serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis. Inhibition of aurora kinases may result in an inhibition of cellular division and proliferation in tumor cells that overexpress aurora kinases.