Single Biggest Cancer Dictionary in the World
What is anti-TGF-beta monoclonal antibody SAR-439459?
Pronunciation: /ˈænˌti tgf* ˈbeɪtə ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi sɑr fɔr ˈhənərd ənd thirty-nine* ˈθaʊzənd, fɔr ˈhənərd ənd fifty-nine*/
anti-TGF-beta monoclonal antibody SAR-439459
Definition
A monoclonal antibody (mAb) directed against human transforming growth factor beta (TGF-beta; TGFb), with potential antineoplastic activity. Upon administration, anti-TGF-beta monoclonal antibody SAR-439459 specifically targets and binds to TGF-beta, thereby preventing the activation of TGF-beta-mediated signaling pathways. This may inhibit the proliferation of tumor cells in which TGF-beta is overactivated. TGF-beta, a pro-inflammatory mediator that is mutated and/or overexpressed in a variety of cancer cell types, is involved in cancer cell proliferation and migration, and in tumor progression.