Definition

A humanized monoclonal antibody directed against human plectin (plectin-1; plectin 1), with potential antineoplastic activity. Upon administration, anti-plectin monoclonal antibody ZB131 specifically binds to plectin expressed on the cell surface of cancer cells, thereby activating the immune system to induce an anti-tumor T-cell response against plectin-expressing cancer cells and inducing apoptosis in these cancer cells. Plectin, a pro-tumorigenic protein, is normally found inside the cytoplasm of healthy cells but is only selectively expressed on the cell surface of various cancer cells. Cancer-specific plectin (CSP), also known as cell surface plectin-1 (CSP1), plays an important role in cancer cell proliferation, migration and invasion.