Single Biggest Cancer Dictionary in the World
What is anti-LGR5 monoclonal antibody BNC101?
Pronunciation: /ˈænˌti lgr* faɪv ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi bnc* wən ˈhənərd ənd wən/
anti-LGR5 monoclonal antibody BNC101
Definition
A humanized monoclonal antibody targeting leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), with potential antineoplastic activity. Upon administration, the anti-LGR5 humanized monoclonal antibody BNC101 targets and binds to LGR5, thereby inhibiting LGR5-mediated signal transduction pathways. This prevents proliferation of LGR5-expressing tumor cells. LGR5, a member of the Wnt signaling pathway, is a cancer stem cell (CSC) receptor overexpressed on certain cancer cells; it plays a key role in CSC proliferation and survival.