Definition

A humanized, afucosylated monoclonal antibody directed against killer cell lectin-like receptor G1 (KLRG1), with potential immunomodulatory activity. Upon administration, anti-KLRG1 monoclonal antibody ABC008 targets and binds to KLRG1 expressed on highly differentiated effector CD8+ cytotoxic T cells, and selectively depletes these highly differentiated cytotoxic T cells while sparing other immune cells. This prevents the killing of cells by these highly differentiated cytotoxic T cells in certain autoimmune diseases, such as the destruction of muscle tissue in inclusion body myositis, and the destruction of neutrophils and red blood cell precursors in T-cell large granular lymphocytic leukemia (T-LGLL).