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What is anti-human cytomegalovirus monoclonal antibody combination CSJ-148?
Pronunciation: /ˈænˌti ˈjumən ˌsaɪtəˌmɛgəloʊˈvaɪrəs ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi ˌkɑmbəˈneɪʃən csj* wən ˈhənərd ənd forty-eight*/
anti-human cytomegalovirus monoclonal antibody combination CSJ-148
Definition
A combination agent composed of two human monoclonal antibodies against the human cytomegalovirus (HCMV), LJP538 and LJP539, with potential immunomodulating activity. Upon administration of CSJ-148, both LJP538 and LJP539 bind to and inhibit the function of viral HCMV glycoproteins that are essential for HCMV infection; LJP538 targets and binds to glycoprotein B (gB) and LJP539 targets and inhibits the pentameric complex, consisting of glycoproteins gH, gL, UL128, UL130, and UL131. Human cytomegalovirus (HCMV) can cause significant disease in immunocompromised patients.