Single Biggest Cancer Dictionary in the World
What is anti-folate receptor alpha antibody-drug conjugate AMT-151?
Pronunciation: /ˈænˌti folate* riˈsɛptər ˈælfə ˈæntɪˌbɑdi drəg ˌkɑnʤəˈgeɪt amt* wən ˈhənərd ənd fifty-one*/
anti-folate receptor alpha antibody-drug conjugate AMT-151
Definition
An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting folate receptor alpha (FRa; FolRa; FOLR1) conjugated to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration of anti-FRa ADC AMT-151, the antibody moiety targets and binds to FRa expressed on tumor cells. Upon cellular uptake and internalization, the cytotoxic agent inhibits tumor cell proliferation through an as of yet undisclosed mechanism of action (MoA). FRa is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues.