Single Biggest Cancer Dictionary in the World
What is anti-FGFR3 antibody-drug conjugate LY3076226?
Pronunciation: /ˈænˌti fgfr* θri ˈæntɪˌbɑdi drəg ˌkɑnʤəˈgeɪt laɪ θri ˈmɪljən, seventy-six* ˈθaʊzənd, tu ˈhənərd ənd twenty-six*/
anti-FGFR3 antibody-drug conjugate LY3076226
Definition
An antibody-drug conjugate (ADC) composed of a human monoclonal antibody against the fibroblast growth factor receptor type 3 (FGFR3) that is conjugated to an undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration, the antibody moiety of anti-FGFR3 ADC LY3076226 binds to FGFR3. Upon internalization, the cytotoxic moiety causes cell death in FGFR3-expressing tumor cells. FGFR3, a receptor tyrosine kinase upregulated or mutated in many tumor cell types, plays a key role in tumor cell proliferation.