Definition

A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the immunosuppressive receptor CD163 (scavenger receptor cysteine-rich type 1 protein M130), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CD163 monoclonal antibody OR2805 targets and binds to CD163 expressed on immunosuppressive tumor-associated macrophages (TAMs) within the tumor microenvironment (TME), and prevents the binding of CD163 to its ligands. This inhibits CD163-mediated immunosuppression, including the secretion of immunosuppressive cytokines and the inhibition of T-cell activation. This enhances T-cell activation and proliferation and antitumor T-cell immune responses, which inhibits the proliferation of tumor cells. CD163, an immunosuppressive receptor highly expressed on TAMs, plays an important role in immunosuppression and the inhibition of anti-tumor T-cell immune responses.