Single Biggest Cancer Dictionary in the World
What is anti-CA19-9 monoclonal antibody 5B1?
Pronunciation: /ˈænˌti ˈsiˈeɪ ˈnaɪnˈtin naɪn ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi faɪv bi wən/
anti-CA19-9 monoclonal antibody 5B1
Definition
A human monoclonal antibody against the carbohydrate antigen sialyl-Lewis A (carbohydrate antigen 19-9; CA19-9), with potential antineoplastic activity. Upon administration, monoclonal antibody 5B1 binds to CA19-9 and kills CA19-9-expressing tumor cells, possibly through the induction of both complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC). CA19-9 is overexpressed on a number of different tumor cell types, and plays a key role in tumor cell survival and metastasis.