Single Biggest Cancer Dictionary in the World
What is
anti-C4.4a antibody-drug conjugate BAY1129980
?Pronunciation: /ˈænˌti si fɔr fɔr ə ˈæntɪˌbɑdi drəg ˌkɑnʤəˈgeɪt beɪ wən ˈmɪljən, wən ˈhənərd ənd twenty-nine* ˈθaʊzənd, naɪn ˈhənərd ənd ˈeɪti/
anti-C4.4a antibody-drug conjugate BAY1129980
Definition
An antibody-drug conjugate (ADC) composed of an antibody against a structural homolog of the urokinase-type plasminogen activator receptor (uPAR) and tumor-associated antigen, C4.4a, and conjugated with a cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration, anti-C4.4a antibody-drug conjugate BAY1129980 targets and binds to C4.4a-expressing tumor cells. Upon binding and cell entry, the cytotoxic agent kills the tumor cell. C4.4a, a glycolipid-anchored membrane protein and a member of the Ly-6 family, is overexpressed by a variety of cancer cell types whereas it is minimally expressed on healthy cells.