Single Biggest Cancer Dictionary in the World
What is allogeneic umbilical cord blood-derived CXCR4-enriched T-regulatory cells CK0804?
Pronunciation: /allogeneic* əmˈbɪlɪkəl kɔrd bləd dəraɪvd cxcr* fɔr ɛnˈrɪʧt ti ˈrɛgjələˌtɔri sɛlz ck* eɪt ˈhənərd ənd fɔr/
allogeneic umbilical cord blood-derived CXCR4-enriched T-regulatory cells CK0804
Definition
A preparation of allogeneic T-regulatory cells (Tregs) derived from umbilical cord blood (UCB) and enriched with C-X-C chemokine receptor type 4 (CXCR4), with potential immunomodulatory activity. Upon administration, allogeneic UCB-derived CXCR4-enriched Tregs CK0804 may promote immunologic homeostasis and modulate immune responses. CXCR4 enrichment promotes the traffic of the Tregs to the bone marrow and its retainment in the bone marrow, as bone marrow expresses the CXCR4 ligand stromal cell-derived factor 1 (CXCL12).