Single Biggest Cancer Dictionary in the World

What is allogeneic natural killer cells IDP-023?

Pronunciation: /allogeneic* ˈnæʧərəl ˈkɪlər sɛlz idp* tˈwɛntiθˌri/

allogeneic natural killer cells IDP-023

Definition

A preparation of off-the-shelf (OTS) allogeneic, natural killer (NK) cells that contains g minus NK cells (G-NKs), with potential cytolytic and antineoplastic activities. Upon administration, allogeneic NK cells IDP-023 recognize and lyse cancer cells. These cells also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response. G-NKs are deficient in the FceR1g protein and show increased cytokine secretion, higher levels of cytolytic enzymes, increased persistence, and higher antibody dependent cell mediated cytotoxicity (ADCC) when combined with monoclonal antibody treatment.