Single Biggest Cancer Dictionary in the World
What is allogeneic gene-edited CD33-knockout hematopoietic stem and progenitor cells?
Pronunciation: /allogeneic* ʤin ˈɛdɪtɪd ˈsiˈdi thirty-three* ˈnɑˌkaʊt hematopoietic* stɛm ənd proʊˈʤɛnɪtər sɛlz/
allogeneic gene-edited CD33-knockout hematopoietic stem and progenitor cells
Definition
A preparation of human allogeneic hematopoietic stem and progenitor cells (HSPCs) that are ex-vivo gene-edited to remove the cluster of differentiation 33 (CD33) antigen, that can potentially be used to improve hematopoietic recovery after hematopoietic cell transplantation (HCT) and CD33-targeting therapy. Upon administration, allogeneic gene-edited CD33-knockout HSPCs increase and restore the number of HSPCs, which may prevent or decrease infection and other complications of HCT and chemotherapy-induced neutropenia (CIN). The removal of CD33 protects the agent from the cytotoxic effects of CD33-targeted agents administered after HCT.