Single Biggest Cancer Dictionary in the World
What is
allogeneic CD56-positive CD3-negative natural killer cells CYNK-001
?Pronunciation: /allogeneic* ˈsiˈdi fifty-six* ˈpɑzətɪv ˈsiˈdi θri ˈnɛgətɪv ˈnæʧərəl ˈkɪlər sɛlz cynk* wən/
allogeneic CD56-positive CD3-negative natural killer cells CYNK-001
Definition
A population of cryopreserved, off-the-shelf (OTS) allogeneic natural killer (NK) cells derived from human placental hematopoietic stem cells (HSCs) and expressing the CD56 surface antigen and exhibiting a lack of CD3, with potential immunomodulating, antineoplastic and antiviral activities. Upon infusion of allogeneic CD56-positive CD3-negative NK cells CYNK-001, these cells are able to recognize tumor cells as well as virally-infected cells, secrete perforins, granzymes and cytokines, and induce apoptosis in tumor and virally-infected cells.