Single Biggest Cancer Dictionary in the World
What is allogeneic B7.1/HLA-A1 transfected tumor cell vaccine?
Pronunciation: /allogeneic* bi ˈsɛvən wən hla* ə wən transfected* ˈtumər sɛl ˌvækˈsin/
allogeneic B7.1/HLA-A1 transfected tumor cell vaccine
Definition
An allogeneic whole cell vaccine, derived from irradiated allogenic tumor cells manipulated to express human B7.1 (CD80 antigen) and human leukocyte antigen (HLA) A1, with potential antitumor activity. Vaccination with allogeneic B7.1/HLA-A1 transfected tumor cell vaccine may elicit a cytotoxic T lymphocyte (CTL) response against similar host tumor cells, resulting in decreased tumor cell proliferation.