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What is ALDH2 activator FP-045?

Pronunciation: /aldh* tu ˈæktəˌveɪtər fp* ˈfɔrtiˌfaɪv/

ALDH2 activator FP-045

Definition

An orally bioavailable selective activator of the mitochondrial isoform of aldehyde dehydrogenase (ALDH2), with potential protective activity. Upon oral administration, ALDH2 activator FP-045 increases ALDH2 activity. This increases the metabolism of toxic reactive aldehydes and lowers the level of the toxic aldehydes. This may protect cells from the toxic aldehydes and prevent mitochondria diseases and disorders. ALDH2, a mitochondrial regulator of toxic aldehyde metabolism, plays an important role in the metabolism of toxic aldehydes. Toxic aldehydes are produced by oxidative stress.