Definition

An orally bioavailable, probiotic supplement containing Akkermansia muciniphila (A. muciniphila), a naturally occurring bacterium found in the healthy human gastrointestinal (GI) tract, with potential immunomodulating and mucosal protective activities. Upon oral administration of A. muciniphila probiotic, A. muciniphila may help maintain adequate colonization of the GI tract by modulating the composition of the normal microflora. During colonization in the GI tract, the bacteria may form a protective intestinal barrier that may help maintain gut lining and prevent both damage to the mucosal epithelia caused by toxins and attachment of potential pathogens, thereby protecting against bacterial translocation and infection. In addition, the probiotic bacteria may potentiate immunity and may improve response to certain cancer immunotherapies.