Single Biggest Cancer Dictionary in the World

What is AEE788?

Pronunciation: /aee* ˈsɛvən ˈhənərd ənd eighty-eight*/

AEE788

Definition

An orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis.