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What is
abiraterone amorphous solid dispersion formulation DST-2970
?Pronunciation: /abiraterone* əˈmɔrfəs ˈsɑləd dɪˈspərʒən ˌfɔrmjəˈleɪʃən dst* tu ˈθaʊzənd, naɪn ˈhənərd ənd ˈsɛvənti/
abiraterone amorphous solid dispersion formulation DST-2970
Definition
An orally bioavailable, amorphous solid dispersion formulation of the steroidal compound abiraterone, with potential antiandrogen activity. Upon oral administration, abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex; CYP17A1), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. This may suppress testosterone production by both the testes and the adrenals to castrate-range levels.