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What is
18F-fluoromisonidazole
?Pronunciation: /ˈeɪˈtin ɛf fluoromisonidazole*/
18F-fluoromisonidazole
Definition
A radiofluorinated 2-nitroimidazole derivate with hypoxia-specific tracer activity. Misonidazole is reduced under hypoxic conditions and in reduced form covalently binds to macromolecules in hypoxic cells. 18F (fluorine-18) radiofluorination of misonidazole to form 18F-fluoromisonidazole allows radioisotopic imaging of reduced misonidazole bound to macromolecules in hypoxic cells.