Single Biggest Cancer Dictionary in the World
What is PI3K alpha/mTOR inhibitor PWT33597 mesylate?
Pronunciation: /paɪ θri keɪ ˈælfə mtor* ˌɪnˈhɪbətər pwt* thirty-three* ˈθaʊzənd, faɪv ˈhənərd ənd ninety-seven* mesylate*/
PI3K alpha/mTOR inhibitor PWT33597 mesylate
Definition
The mesylate salt form of PWT33597, an orally bioavailable dual inhibitor of phosphatidylinositide 3-kinase (PI3K) alpha and mammalian target of rapamycin (mTOR) kinase with potential antineoplastic activity. PI3K alpha/mTOR dual inhibitor PWT33597 selectively inhibits both PI3K alpha kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in PI3K/mTOR-overexpressing tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.