Single Biggest Cancer Dictionary in the World
What is
autologous tolerogenic proinsulin peptide-loaded dendritic cells PIpepTolDC
?Pronunciation: /autologous* tolerogenic* proinsulin* ˈpɛpˌtaɪd ˈloʊdɪd dɛnˈdrɪtɪk sɛlz pipeptoldc*/
autologous tolerogenic proinsulin peptide-loaded dendritic cells PIpepTolDC
Definition
A vaccine composed of autologous tolerogenic dendritic cells (DCs) loaded with the beta cell protein proinsulin peptide (PIpep), C19-A3, with potential immunosuppressive and immune-regulating activities. Upon intradermal administration, the autologous tolerogenic PIpep-loaded DCs may induce proinsulin-specific regulatory T cells (Tregs). This may suppress the autoimmune destruction of the insulin-producing beta cells, thereby protecting the beta cells.