Single Biggest Cancer Dictionary in the World
What is antibody-drug conjugate SHR-A1921?
Pronunciation: /ˈæntɪˌbɑdi drəg ˌkɑnʤəˈgeɪt shr* ə wən ˈθaʊzənd, naɪn ˈhənərd ənd tˈwɛntiˌwɔn/
antibody-drug conjugate SHR-A1921
Definition
An antibody-drug conjugate (ADC) composed of an as of yet undisclosed monoclonal antibody against a tumor-associated antigen (TAA) linked to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration, the monoclonal antibody moiety of SHR-A1921 targets and binds to the TAA expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills the TAA-expressing cancer cells, through an as of yet unknown mechanism of action.