Definition

A bispecific T-cell engager directed against the tumor-associated antigen (TAA) tyrosinase-related protein 1 (TYRP1; TRP1; glycoprotein 75; gp75) and the CD3 antigen found on T lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-TYRP1/CD3 T-cell engager RO7293583 binds to both CD3 on cytotoxic T lymphocytes (CTLs) and TYRP1 found on TYRP1-expressing tumor cells. This activates and redirects CTLs to TYRP1-expressing tumor cells, which results in the CTL-mediated death of TYRP1-expressing tumor cells. TYRP1, a transmembrane glycoprotein, is involved in melanin biosynthesis and is expressed in melanosomes of human melanocytes and melanomas.