Definition

A bispecific antibody directed against the tumor-associated antigen (TAA) glypican-3 (GPC3; GPC-3) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3/anti-CD3 bispecific antibody CM350 binds to both CD3 on cytotoxic T lymphocytes (CTLs) and GPC3 on GPC3-expressing tumor cells. This activates and redirects CTLs to GPC3-expressing tumor cells, leading to CTL-mediated killing of GPC3-expressing tumor cells. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells. GPC3 plays an important role in tumor cell proliferation in various tumor cell types.