Single Biggest Cancer Dictionary in the World
What is anti-CD38/CD3 bispecific monoclonal antibody XmAb18968?
Pronunciation: /ˈænˌti ˈsiˈdi thirty-eight* ˈsiˈdi θri bispecific* ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi xmab* ˈeɪˈtin ˈθaʊzənd, naɪn ˈhənərd ənd sixty-eight*/
anti-CD38/CD3 bispecific monoclonal antibody XmAb18968
Definition
A bispecific monoclonal antibody targeting CD3, a T-cell surface antigen, and CD38, a human cell surface glycoprotein and tumor-associated antigen (TAA), with potential antineoplastic activity. Upon administration, anti-CD3/CD38 bispecific monoclonal antibody XmAb18968 binds to both CD3 on T cells and CD38 expressed on tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies; its expression has been correlated with poor prognosis.