Single Biggest Cancer Dictionary in the World
What is anti-CD33 monoclonal antibody BI 836858?
Pronunciation: /ˈænˌti ˈsiˈdi thirty-three* ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi baɪ eɪt ˈhənərd ənd thirty-six* ˈθaʊzənd, eɪt ˈhənərd ənd fifty-eight*/
anti-CD33 monoclonal antibody BI 836858
Definition
An engineered, fully human, immunoglobulin (Ig) G1 anti-CD33 monoclonal antibody, with potential antineoplastic activity. Upon administration, anti-CD33 monoclonal antibody BI 836858 induces an antibody-dependent cellular cytotoxicity (ADCC) against CD33-expressing tumor cells, leading to cell death. CD33, a cell surface antigen expressed on normal non-pluripotent hematopoietic stem cells, is overexpressed on myeloid leukemia cells.