Single Biggest Cancer Dictionary in the World
What is anti-CD133-CAR vector-transduced allogeneic T lymphocytes?
Pronunciation: /ˈænˌti ˈsiˈdi wən ˈhənərd ənd thirty-three* kɑr ˈvɛktər transduced* allogeneic* ti ˈlɪmfəˌsaɪts/
anti-CD133-CAR vector-transduced allogeneic T lymphocytes
Definition
A preparation of allogeneic peripheral blood T lymphocytes (PBTL) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the chimeric CD (cluster of differentiation) 133 antigen receptor, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD133-CAR vector-transduced allogeneic T lymphocytes specifically recognize and kill CD133-expressing tumor cells. CD133, a tumor associated antigen (TAA), is overexpressed on a variety of tumor cell types.