Single Biggest Cancer Dictionary in the World
What is actinium Ac-225 anti-PSMA monoclonal antibody J591?
Pronunciation: /actinium* ˈeɪˈsi tu ˈhənərd ənd tˈwɛntiˌfaɪv ˈænˌti psma* ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi ʤeɪ faɪv ˈhənərd ənd ninety-one*/
actinium Ac-225 anti-PSMA monoclonal antibody J591
Definition
A radioimmunoconjugate consisting of a humanized monoclonal antibody directed against prostate specific membrane antigen (PSMA) labeled with the alpha particle-emitting radioisotope actinium Ac-225, with potential antineoplastic activity. Upon administration, actinium Ac-225 anti-PSMA monoclonal antibody J591 binds to the extracellular domain of PSMA with high affinity, thereby delivering alpha radiation to PSMA expressing cells. PSMA, a type II membrane protein expressed in all types of prostatic tissues, is often overexpressed in tumor cells.