Definition

A condition in which the ovaries stop working and menstrual periods stop before age 40. This can cause fertility problems and symptoms of menopause. In secondary ovarian insufficiency, the ovaries are normal but there is a problem getting hormone signals to them from the brain. This is usually caused by diseases of the pituitary gland or hypothalamus. Secondary ovarian insufficiency may also be caused by certain medicines, too much exercise, or certain eating disorders. Some women with secondary ovarian insufficiency sometimes have menstrual periods and may be able to have children. Also called secondary ovarian failure.