Definition

A gene that makes a protein that is found inside small structures in cells called mitochondria and that helps the mitochondria make energy for many cell functions. Mutations (changes) in the isocitrate dehydrogenase-2 gene have been found in certain genetic conditions and in some types of cancer, including acute myelogenous leukemia and brain cancer. These changes may cause abnormal cells, including cancer cells, to grow and spread in the body. Also called IDH2 gene.