Definition

A drug used in adults to treat non-small cell lung cancer that has spread and is ROS1 positive and in adults and children aged 1 month and older to treat certain types of solid tumors that have an NTRK gene fusion. It is also being studied in the treatment of other types of cancer. Entrectinib blocks certain proteins involved in cell signaling and cell growth. Blocking these proteins may help keep cancer cells from growing and may kill them. Entrectinib is a type of tyrosine kinase inhibitor. Also called Rozlytrek.