Single Biggest Cancer Dictionary in the World
What is variant of uncertain significance?
Pronunciation: /ˈvɛriənt əv ənˈsərtən sɪgˈnɪfɪkəns/
variant of uncertain significance
Definition
A change in a gene’s DNA sequence that has an unknown effect on a person’s health. There is usually not enough information about a variant of uncertain significance to know whether it increases a person’s risk of developing a disease, such as cancer. Also called unclassified variant, variant of unknown significance, and VUS.