Definition

Stage IV is divided into stages IVA and IVB. In stage IVA, cancer is found in one or both sides of the prostate and may have spread to the seminal vesicles or to nearby tissue or organs, such as the rectum, bladder, or pelvic wall. Cancer has spread to nearby lymph nodes. The prostate-specific antigen (PSA) can be any level and the Grade Group is 1, 2, 3, 4, or 5 (Gleason score is 10 or less). In stage IVB, cancer has spread to other parts of the body, such as the bones or distant lymph nodes.