Definition

A gene that makes a protein that is a type of keratin involved in forming the structure of certain cells, especially those that make up the skin, hair, and nails, and in the development of skin color. Mutations (changes) in the KRT5 gene have been found in an inherited condition called epidermolysis bullosa simplex, which causes the skin to tear and blister easily. People with this condition have an increased risk of developing skin cancer.