Definition

A type of protein found on the surface of cells that helps them attach to, and communicate with, nearby cells. Integrins also help cells attach to large molecules in the extracellular matrix, the substance that surrounds and gives structure to cells. Integrins help cells receive signals from other cells and from the surrounding environment, and they help control the activity of certain genes. They play an important role in cell growth, cell movement, and other cell functions. Integrins are involved in wound healing, blood vessel growth, and in the growth and spread of cancer cells. Drugs that target integrins are being studied in the treatment of some types of cancer.