Definition

A protein that is involved in making cancer cells resistant (unable to respond) to anticancer drugs. Normally, BCRP works with other proteins to help move many different substances, including drugs and other chemicals, in and out of cells. It is found in stem cells and in normal tissues, including the intestine, liver, brain, and placenta. However, it may also be found in higher than normal amounts in some cancer cells, which can cause them to be unable to respond to certain anticancer drugs. Drugs that block BCRP are being studied in the treatment of some types of cancer. BCRP was first identified in breast cancer cells. Also called breast cancer resistance protein.